Public sanitation, and other papers by Whiting Clement Adelbert 1856-1914

Author:Whiting, Clement Adelbert, 1856-1914
Language: eng
Format: epub
Tags: Medicine
Publisher: [Chicago] A. T. Still research institute, Publication bureau
Published: 1916-03-25T05:00:00+00:00

This malignant growth once started may develop either slowly or rapidly. It certainly appears in many cases that the development is slow and while it may occasion more or less suffering, it may not materially shorten the life of the patient. On the other hand, the development may be so rapid in character as to present a most serious problem, both to the physician and the surgeon.

It would not be proper to close a paper of this character without calling attention to the increasing importance which the endothelial cells of capillary blood vessels are assuming in the minds of the best pathologists. It is barely possible that many abnormal growths which have been attributed either to epithelial, muscular or connective tissue cells may have arisen from the endothelial cells of capillary blood vessels. Should further investigation prove this to be the case, it would be a reason for our attaching even more significance to circulation than we do at the present time.

*SOME EXPERIMENTS WITH THE OPSONIC INDEX.

During the years 1909 and 1910, I made a scries of careful experiments to determine whether or not it was possible to affect the opsonic index of an individual by mechanical manipulation. This-series of experiments was made upon myself, the report forwarded to the Research Institute and published in its first bulletin.

During the years 1910 and 1911 I made another series of experiments. Some of these were made upon a person known to be the victim of chronic tuberculosis; others were made upon persons supposed to be entirely free from tubercular taint. As this report may possibly be made the basis for other work, I present my results in tabulated form and give a brief description of my methods, so that every one may be in a position to judge of the value of the work.

In every case I used the leucocytes from my own blood. I obtained blood serum from the person who was to be experimented upon and determined the opsonizing power of this serum. The person was then placed upon a table and the splanchnic area of the back was highly stimulated. The subject was then placed on his back and direct and heavy stimulation was applied over the region of the liver. The whole process of stimulation occupied perhaps twenty minutes of time.

From half an hour to two hours after this stimulation, blood was again drawn from the patient and its serum separated from it. The test was of course made by comparing the opsonizing power of the serum obtained before the stimulation with the serum obtained after the stimulation.

The first person experimented on was Miss L., who is a victim of chronic tuberculosis. The experiments were made by taking her serum and then subjecting her to stimulation as already described and after the stimulation again taking blood from which the serum was obtained.

The chief value, as I understand it, which centers around this work, lies in the fact that phagocytosis appears to be greatly increased by mechanical manipulation. It

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